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KMID : 0363320040250010059
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Journal of Korean Oriental Internal Medicine
2004 Volume.25 No. 1 p.59 ~ p.70
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The Effects of Chungganhaeju-tang(Qingganjiejiu-tang) on NF{kappa}B Activation and Apoptosis of Kupffer Cells
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Han Chang-Woo
Kim Young-Chul
Lee Jang-Hoon
Woo Hong-Jung
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Abstract
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Objectives : Previous studies showed that treatment with Chungganhaeju-tang prevents hepatic inflammation and apoptosis in alcoholic liver disease. The purpose of our study is to determine if any relations exsists between the transcription factor NF{kappa}B, an orchestrating expression of a large number of genes and inhibitory effects of Chungganhaeju-tang on ethanol induced apoptosis.
Materials and Methods : To assess the role of NF{kappa}B, we blocked NFkB activation by delivering to the kupffer cells I{kappa}B{Delta}N, a dominant negative NF{kappa}B inhibitor, and investigated if Chungganhaeju-tang still prevented apoptosis.
Results : When NF{kappa}B activation was blocked, there was no inhibitory effect of Chungganhaeju-tang on ethanol induced apoptosis of kupffer cells.
Conclusion : This result suggests that Chungganhaeju-tang protects the liver from ethanol induced apoptosis by activating the NF{kappa}B that plays a key role in porotecting mechanism and reducing inflammatory cytokine gene expression.
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KEYWORD
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Chungganhaeju-tang(Qingganjiejiu-tang), kupffer cell, apoptosis, NF{kappa}B
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